Maternal vitamin [D.sub.3] supplementation at 50 [micro]g/d protects against low serum 25-hydroxyvitamin D in infants at 8 wk of age: a randomized controlled trial of 3 doses of vitamin D beginning in gestation and continued in lactation

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From: American Journal of Clinical Nutrition(Vol. 102, Issue 2)
Publisher: American Society for Clinical Nutrition, Inc.
Document Type: Author abstract; Report
Length: 300 words

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Abstract :

Background: Vitamin D supplementation is recommended for breastfed infants. Maternal supplementation beginning in gestation is a potential alternative, but its efficacy in maintaining infant 25hydroxyvitamin D [25(OH)D] concentration after birth is unknown. Objectives: We determined the effect of 3 doses of maternal vitamin D supplementation beginning in gestation and continued in lactation on infant serum 25(OH)D and compared the prevalence of infant serum 25(OH)D cutoffs ( 30, 40, 50, and 75 nmol/L) by dose at 8 wk of age. Design: Pregnant women (n = 226) were randomly allocated to receive 10, 25, or 50 [micro]g vitamin [D.sub.3]/d from 13 to 24 wk of gestation until 8 wk postpartum, with no infant supplementation. Mother and infant blood was collected at 8 wk postpartum. Results: At 8 wk postpartum, mean [nmol/L (95% CI)] infant 25(OH)D at 8 wk was higher in the 50-[micro]g/d [75 (67, 83)] than in the 25-[micro]g/d [52 (45, 58)] or 10-[micro]g/d [45 (38, 52)] vitamin D groups (P 75 nmol/L compared with 44% in the 50-[micro]g/d group (P 30 nmol/L. At 8 wk postpartum, mean maternal 25(OH)D concentration was higher in the 50-[micro]g/d [88 (84, 91)] than in the 25-[micro]g/d [78 (74, 81)] or 10-[micro]g/d [69 (66, 73)] groups (P Conclusions: Maternal supplementation beginning in gestation with 50 [micro]g vitamin [D.sub.3]/d protects 98% of unsupplemented breastfed infants against 25(OH)D deficiency ( Keywords: vitamin D, 25(OH)D, supplement, pregnancy, lactation, postpartum, infant doi: 10.3945/ajcn.114.106385

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Gale Document Number: GALE|A426765859