Comprehensive description of the current breast cancer microenvironment advancements via single-cell analysis.

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Date: Apr. 27, 2021
Publisher: BioMed Central Ltd.
Document Type: Article
Length: 9,459 words
Lexile Measure: 1590L

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Abstract :

Breast cancer is a heterogeneous disease with a complex microenvironment consisting of tumor cells, immune cells, fibroblasts and vascular cells. These cancer-associated cells shape the tumor microenvironment (TME) and influence the progression of breast cancer and the therapeutic responses in patients. The exact composition of the intra-tumoral cells is mixed as the highly heterogeneous and dynamic nature of the TME. Recent advances in single-cell technologies such as single-cell DNA sequencing (scDNA-seq), single-cell RNA sequencing (scRNA-seq) and mass cytometry have provided new insights into the phenotypic and functional diversity of tumor-infiltrating cells in breast cancer. In this review, we have outlined the recent progress in single-cell characterization of breast tumor ecosystems, and summarized the phenotypic diversity of intra-tumoral cells and their potential prognostic relevance. Keywords: Breast cancer, Tumor microenvironment, Single-cell RNA sequencing, Single-cell DNA sequencing

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Gale Document Number: GALE|A661419464