Preexisting memory CD[4.sup.+] T cells contribute to the primary response in an HIV-1 vaccine trial.

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From: Journal of Clinical Investigation(Vol. 131, Issue 23)
Publisher: American Society for Clinical Investigation
Document Type: Report
Length: 4,125 words
Lexile Measure: 1400L

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Abstract :

Naive and memory CD[4.sup.+] T cells reactive with human immunodeficiency virus type 1 (HIV-1) are detectable in unexposed, unimmunized individuals. The contribution of preexisting CD[4.sup.+] T cells to a primary immune response was investigated in 20 HIV-1-seronegative volunteers vaccinated with an HIV-1 envelope (Env) plasmid DNA prime and recombinant modified vaccinia virus Ankara (MVA) boost in the HVTN 106 vaccine trial ( NCT02296541). Prevaccination naive or memory CD[4.sup.+] T cell responses directed against peptide epitopes in Env were identified in 14 individuals. After priming with DNA, 40% (8/20) of the elicited responses matched epitopes detected in the corresponding preimmunization memory repertoires, and clonotypes were shared before and after vaccination in 2 representative volunteers. In contrast, there were no shared epitope specificities between the preimmunization memory compartment and responses detected after boosting with recombinant MVA expressing a heterologous Env. Preexisting memory CD[4.sup.+] T cells therefore shape the early immune response to vaccination with a previously unencountered HIV-1 antigen.

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Gale Document Number: GALE|A687390430