Simultaneous Determination of Bisphenol A, Bisphenol F, 4-Nonylphenol, 4-n-Nonylphenol, and Octylphenol in Grease-Rich Food by Carb/PSA Solid-Phase Extraction Combined with High-Performance Liquid Chromatography Tandem Mass Spectrometry

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From: Food Analytical Methods(Vol. 11, Issue 2)
Publisher: Springer
Document Type: Report
Length: 282 words

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To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: Byline: Zhiming Hao (1), Yanping Xiao (1), Lanlan Jiang (2), Weidong Bai (3), Wenshan Huang (4), Lipeng Yuan (1) Keywords: Phenols; Grease-rich food; Solid-phase extraction; HPLC-MS/MS; Isotope internal standard method Abstract: A solid-phase extraction (SPE) combined with high-performance liquid chromatography--tandem mass spectrometry (HPLC-MS/MS) method was developed to determine five phenols in grease-rich food (i.e., hotpot seasoning). Sample added with isotope internal standards bisphenol A-d .sub.4 (BPA-d .sub.4) and 4-n-nonylphenol-d .sub.4 (4-n-NP-d .sub.4) was dispersedly dissolved in n-hexane. After centrifugation, the supernatant was purified by Carb/PSA SPE. Then, target analytes were separated on a Waters XBridge C18 column, detected under multiple reaction monitoring (MRM) mode. The developed method was validated in terms of linearity, limit of quantitation (LOQ), recovery, and precision. Results found that linear relations were favorable in the selected concentration range of 0.5--100 [micro]g/L for all phenols, with R .sup.2 greater than 0.995. LOQs were between 1.0 and 2.0 [micro]g/kg. The mean recoveries for negative sample at three spiked concentration levels were in the range of 83.5--97.1%, and the intra-day and inter-day precision were calculated between 4.7 and 12.5%. This method is accurate and sensitive and has good purifying effect, which can be applied for screening and quantitation of target phenols in grease-rich food. Author Affiliation: (1) Guangdong Agriculture Industry Business Polytechnic College, Guangzhou, China (2) Guangzhou Quality Supervision and Testing Institute, Guangzhou, China (3) College of Light Industry and Food Sciences, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, China (4) Beijing University of Chemical Technology, Beijing, China Article History: Registration Date: 21/08/2017 Received Date: 05/07/2017 Accepted Date: 20/08/2017 Online Date: 30/08/2017

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Gale Document Number: GALE|A521174772