Meta-analysis of the correlation between dietary copper supply and broiler performance

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Date: May 18, 2020
From: PLoS ONE(Vol. 15, Issue 5)
Publisher: Public Library of Science
Document Type: Report
Length: 4,548 words
Lexile Measure: 1420L

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Author(s): Chao Feng 1,*, Bin Xie 1, Qiqige Wuren 2, Minghua Gao 1

1. Introduction

Copper plays a vital role in the growth of broilers, having significant influences on the maintenance of production performance and regulation of enzymatic activity and on bone growth, glucose metabolism, hemoglobin synthesis, cardiovascular structural integrity, and other physiological functions [1]. According to NRC (1994), the dietary copper requirement of broilers is 8 mg/kg [2], and a higher dose is often given in the production process to obtain better economic benefits yet [3]. It cannot be ignored that excessive copper addition, which occurs because of the cost-effectiveness and easy availability, also causes environmental pollution and waste. Today, the optimum addition of dietary copper is still controversial. Therefore, the level of copper addition urgently needs to be reassessed. Studies have shown that with increasing copper level (100-300 mg/kg), the live performance of broilers is improved [4-6]. Some researchers suggested that feeding 250 ppm of Cu during the starter period had negative consequences on bird performance, and moderate levels of Cu (125 ppm) had beneficial effects on bird performance at market age [7]. Based on studies of the relationship between high levels of dietary copper (100-300 mg/kg) and the performance of broilers, it has been suggested that Cu had an apparent inhibitory effect on the cholesterol content, which can significantly improve the survival rate of broiler offspring [8-9]. In addition, copper oversupply (greater than 300 mg/kg) may inhibit the growth of broilers [10]. Meta-analysis is a kind of statistical method that integrates research results of all types in the same field. The differences between studies are removed by meta-analysis, which can make the corrected data comparable, creating more objective and convincing data [11]. The main goal of this study is to explore the relationship between copper addition and broiler performance reported by different studies through meta-analysis and obtain a reasonable quantitative model to explain the observed value and provide a theoretical reference for the practical process of Cu addition.

2. Materials and methods

2.1. Dataset

All kinds of randomized controlled trial (RCT) studies published up to January 2019 were retrieved from the Web of Science, Springer, Elsevier, ScienceDirect, and Taylor & Francis Online databases, the Journal of Dairy Research and China National Knowledge Infrastructure (CNKI). The following search terms were used: (broiler or chick*) and (performance or growth) and copper We used broiler, performance, and copper as the keywords to search in the databases listed above, not including papers in conference proceedings and unpublished results. The selected studies met the following criteria: they were published in English or Chinese, used a corn and soybean meal-based diet, had a 21-day experimental period, provided the specific Cu addition values (inorganic), and pertained to non-indigenous breeds. Newborn broilers are divided into groups based on the copper supply they receive. In the control group, the copper supply was zero, and the copper supply in the experimental group ranged from 4 mg/kg to 800 mg/kg. During a 21-day period, the weight changes in the broilers (the...

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