BYHWD Alleviates Inflammatory Response by NIK-Mediated Repression of the Noncanonical NF-[kappa]B Pathway During ICH Recovery.

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Date: May 7, 2021
Publisher: Frontiers Research Foundation
Document Type: Article
Length: 402 words
Lexile Measure: 1360L

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Author(s): Wei Xiao, Zehui He, Weikang Luo, Dandan Feng, Yang Wang, Tao Tang, Ali Yang, Jiekun Luo

Intracerebral hemorrhage (ICH) is a life-threatening type of stroke that lacks effective treatments. The inflammatory response following ICH is a vital response that affects brain repair and organism recovery. The nuclear factor [kappa]B (NF-[kappa]B) signaling pathway is considered one of the most important inflammatory response pathways and one of its response pathways, the noncanonical NF-[kappa]B signaling pathway, is known to be associated with persistent effect and chronic inflammation. NF-[kappa]B-inducing kinase (NIK) <italic>via</italic> the noncanonical NF-[kappa]B signaling plays a key role in controlling inflammation....

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Gale Document Number: GALE|A661060350