CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System-Results From the ADRED Study.

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Publisher: Frontiers Research Foundation
Document Type: Report
Length: 418 words
Lexile Measure: 1350L

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Author(s): Katja S. Just, Harald Dormann, Mathias Freitag, Marlen Schurig, Miriam Böhme, Michael Steffens, Catharina Scholl, Thomas Seufferlein, Ingo Graeff, Matthias Schwab, Julia C. Stingl

Cytochrome P450 (CYP) 2D6 is a polymorphic enzyme expressed in the central nervous system (CNS), important in drug metabolism and with a potentially constitutive role in CNS function such as vigilance. This study aimed to analyze variability in CYP2D6 activity linked to vigilance-related adverse drug reactions (ADRs) in the CNS. A dataset of N = 2939 ADR cases of the prospective multicenter observational trial in emergency departments (EDs) (ADRED; trial registration: DRKS-ID: DRKS00008979) was analyzed. Dizziness as the most...

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Gale Document Number: GALE|A661060357