Characterization of B- and T-Cell Compartment and B-Cell Related Factors Belonging to the TNF/TNFR Superfamily in Patients With Clinically Active Systemic Lupus Erythematosus: Baseline BAFF Serum Levels Are the Strongest Predictor of Response to Belimumab after Twelve Months of Therapy.

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Publisher: Frontiers Research Foundation
Document Type: Article
Length: 437 words
Lexile Measure: 1510L

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Author(s): Silvia Piantoni, Francesca Regola, Stefania Masneri, Michele Merletti, Torsten Lowin, Paolo AiroÌ, Angela Tincani, Franco Franceschini, Laura Andreoli, Georg Pongratz

<bold>Background:</bold> Patients with systemic lupus erythematosus (SLE) show increased serum levels of tumor necrosis factor (TNF)/TNF receptor (R) superfamily member, e.g. BAFF (B lymphocyte stimulator). Belimumab, a monoclonal antibody against soluble BAFF, is used for treatment of SLE. Although B cells are the main target, a BAFF-dependent T-cell activation pathway also plays a role. High levels of anti-DNA antibodies and low complement at baseline are known predictors of response to Belimumab.

<bold>Objectives:</bold> To explore the association of circulating lymphocytes and serum levels of B- cell related TNF/TNFR superfamily...

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Gale Document Number: GALE|A662534492