Bilobalide Ameliorates Sepsis Induced Acute Lung Injury by Inactivating Toll-Like Receptor 4/Myeloid Differentiation Factor 88/Nuclear Factor-Kappa B Pathway.

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Date: Aug. 2021
Publisher: New Century Health Publishers, LLC
Document Type: Article
Length: 3,159 words
Lexile Measure: 1350L

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Abstract :

Acute lung injury refers to the injury of alveolar epithelial cells and pulmonary capillary endothelial cells caused by noncardiac factors. To better combat the disease, there is an urgent need to develop more effective drugs. Sepsis is a syndrome of systemic inflammation caused by infection, and the molecular mechanism by which sepsis induces acute lung injury has not been clearly determined. Bilobalide is a unique component of Ginkgo biloba. Although it has multiple biological functions, its role in sepsis induced acute lung injury needs further study. In this study, we found that bilobalide alleviated cecal ligation and puncture induced acute lung injury. Additionally, bilobalide regulated cecal ligation and puncture induced lung injury through toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-kappa B pathway. We therefore conclude that bilobalide may be a potential drug for the treatment of sepsis induced acute lung injury. Keywords: Acute lung injury, Bilobalide, Inflammatory response, NF-[KAPPA]B, Sepsis Abbreviations Used: Acute lung injury, ALI; Bronchoalveolar lavage fluid, BALF; Cecal ligation and puncture, CLP; Enhanced chemiluminescence, ECL; Enzyme-linked immunosorbent assay, ELISA; Horse radish peroxidase, HRP; Myeloid differentiation factor 88, MyD88; Nuclear factor-kappa B, NF-[KAPPA]B; Radioimmunoprecipitation assay buffer, RIPA buffer; Toll-like Receptor 4, TLR4; Tumor necrosis factor-[alpha], TNF-[alpha] Corresponding Author: Dr. Fuxiang Fan, Department of General Surgery, The Fourth Affiliated Hospital Zhejiang University School of Medicine, No. N1, Shangcheng Avenue, Yiwu City, Zhejiang Province, China; E-mail: fanfuxiang@zju.edu.cn

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Gale Document Number: GALE|A659263656