Temperature dependence of benzyl-alcohol- and 8-anilinonaphthalene-1-sulfonate-induced aggregation of recombinant human interleukin-1 receptor antagonist

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From: Biochemistry(Vol. 45, Issue 12)
Publisher: American Chemical Society
Document Type: Article
Length: 59 words

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Abstract :

An investigation on the critical role played by temperature in ligand-induced protein aggregation using recombinant human interleukin-1 receptor antagonist (rhIL-1ra) and the ligands benzyl alcohol and 8-anilinonaphthalene-1-sulfonate (ANS) is presented. Results support the conclusion that benzyl alcohol and ANS interact hydrophobically with partially unfolded aggregation-prone protein molecules, resulting in temperature-dependent increases in their levels and acceleration of protein aggregation.

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Gale Document Number: GALE|A146188073