Rapid improvement of the confusional state and electroencephalography after spinal tap in a patient with headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL) syndrome

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Date: November-December 2015
From: Neurology India(Vol. 63, Issue 6)
Publisher: Medknow Publications and Media Pvt. Ltd.
Document Type: Clinical report; Letter to the editor
Length: 526 words
Lexile Measure: 1660L

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Byline: Debopam. Samanta, Erin. Willis


The syndrome of transient headache and neurological deficits associated with cerebrospinal fluid lymphocytosis (HaNDL) is a self-limited, benign entity with an unknown etiology. Neuroimaging studies are usually normal and cerebrospinal fluid (CSF) culture and other tests for determining the etiology remain negative.

A 16-year-old woman, without similar previous history, had an acute onset headache for 10 days prior to her admission to the Intensive Care Unit. Without any definite preceding factor, she started to have a holocephalic stabbing headache for 2–4 h every day that was most prominent around the vertex. It was associated with periorbital pain, photophobia, and nausea. She denied the presence of any visual symptoms. The evening prior to her admission, she noticed left facio-brachial numbness, which soon involved the right side...

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Gale Document Number: GALE|A435999200