To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00345-018-2210-1 Byline: Nurullah Hamidi (1), Erdem Ozturk (2), Taha Numan Yikilmaz (2), Ali Fuat Atmaca (3), Halil Basar (2) Keywords: Colic; Corticosteroid; Pain; Ureter; Urolithiasis; Ureteroscopy Abstract: Purpose To evaluate the effect of corticosteroid (CS) on early postoperative pain, renal colic and total analgesic consumption after uncomplicated and unstented ureteroscopy (URS). Methods Data of 397 patients who underwent URS and stone fragmentation for symptomatic distal ureteral stone (a[currency] 15 mm) were retrospectively evaluated. After exclusion, 72 patients who received methylprednisolone (Group I) after non-stenting uncomplicated URS were matched with another 72 patients who did not receive CS (Group II). Cases were matched 1:1 ratio and the matched-pair criteria were age, stone diameter, and duration of surgery. Results Both groups were statistically similar in terms of mean age, operative time, stone size and preoperative pain score. However, the mean postoperative pain score was statistically significantly lower in group I than group II on the day of surgery (3.3 [+ or -] 1.7 vs. 3.9 [+ or -] 1.3, p = 0.012) and postoperative day 1 (2.8 [+ or -] 1.8 vs. 3.4 [+ or -] 1.3, p = 0.02), respectively. Renal colic episode development rate (4.2 vs. 13.2%, p = 0.036), parenteral analgesic requirement rate (18.1 vs. 33.3%, p = 0.001) and total parenteral analgesic consumption per patient (18 vs. 36mg, p = 0.009) were statistically lower in group I than group II on the day of surgery however, there were no statistically significant differences on postoperative day 1. There were no statistically significant differences between groups in terms of ureteral stenting requirement and late unplanned urgent room visit rates. Conclusions Corticosteroid after uncomplicated URS can be offered to reduce early postoperative pain, renal colic episode and total analgesic consumption. Author Affiliation: (1) 0000 0004 0642 6432, grid.413783.a, Department of Urology, Ataturk Training and Research Hospital, Ankara, Turkey (2) grid.413794.c, Department of Urology, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey (3) grid.488386.9, Department of Urology, Ataturk Training and Research Hospital, Ankara Yildirim Beyazit University School of Medicine, Ankara, Turkey Article History: Registration Date: 24/01/2018 Received Date: 30/10/2017 Accepted Date: 24/01/2018 Online Date: 02/02/2018 Article note: A comment to this article is available online at https://doi.org/10.1007/s00345-018-2324-5.