Ratiometric QD-FRET sensing of aqueous H.sub.2S in vitro

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From: Analytical Chemistry(Vol. 88, Issue 11)
Publisher: American Chemical Society
Document Type: Report
Length: 83 words

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Abstract :

The article reports a platform for the ratiometric fluorescent sensing of endogenously generated H.sub.2S in its aqueous form (bisulfide or hydrogen sulfide anion) based on the alteration of Forster resonance energy transfer from an emissive semiconductor quantum dot (QD) donor to a dithiol-linked organic dye acceptor. The potential for use in biological applications is demonstrated by measuring the response of the QD-based FRET sensor microinjected into live HeLa cells upon extracellular exposure to bisulfide. The methodology is built upon a highly multifunctional platform.

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Gale Document Number: GALE|A456268583