Atractylenolide III Protects Cardiomyocytes from Angiotensin II-Induced Hypertrophy and Apoptosis.

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Date: Nov. 2021
Publisher: New Century Health Publishers, LLC
Document Type: Article
Length: 3,916 words
Lexile Measure: 1330L

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Abstract :

Heart failure is a type of heart disease that causes increased pressure in the heart or a decrease in cardiac output. Unfortunately, despite seriousness of the condition there is a lack of effective early diagnostic markers or effective pharmacotherapy. Atractylodes is known as a tonic herb in ethno-medical systems in East Asia, especially in China, for the treatment of gastrointestinal dysfunction, cancer, osteoporosis, obesity, and fetal irritability. Atractylodes Lactone III is the main active component of Atractylodes rhizome. Atractylodes Lactone III increases the survival and inhibits apoptosis of H9C2 cells induced by angiotensin II. Angiotensin II is closely involved in apoptosis, hypertrophy, and fibrosis of cardiomyocytes, and may be an important cause of the deterioration of cardiovascular disease. Although, Atractylodes Lactone III reduces angiotensin II-induced H9C2 cell hypertrophy by activating the phosphatidylinositol 3-kinase/protein kinase B pathway, the detailed mechanism remains poorly understood. Additionally, inhibition of phosphatidylinositol 3-kinase/protein kinase B pathway inhibits the myocardial protective effect of Atractylodes Lactone III. We therefore hypothesized that Atractylodes Lactone III could serve as a promising therapeutic drug for the treatment of heart failure. Keywords: Angiotensin II, Apoptosis, Atractylodes Lactone III (ATL-III), Heart failure, PI3K/Akt pathway Abbreviations Used: Protein kinase B, AKT; Angiotensin II, Ang II; Atrial natriuretic peptide, ANP; Atractylodes Lactone III, ATL-III; Myosin heavy chain-[beta], [beta]-MHC; Brain natriuretic peptide, BNP; Dulbecco's modified eagle medium, DMEM; Fetal bovine serum, FBS; Flow cytometric, FCM; Glyceraldehyde-3-phosphate dehydrogenase, GAPDH; Heart failure, HF; Nucleotide-binding domain and leucine-rich repeat containing protein 3 (also known as cryopyrin), NLRP3; Phosphatidylinositol 3-kinase, PI3K; Polyvinylidene difluoride, PVDF; Quantitative polymerase chain reaction, qPCR; Renin-angiotensin-aldosterone system, RAAS; Radioimmunoprecipitation assay buffer, RIPA buffer; Sodium dodecyl sulfate polyacrylamide gel-electrophoresis, SDS-PAGE; Standard error of mean, SEM; Tris-buffered saline, TBST; T helper type 1, Th1; T helper type 2, Th2

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Gale Document Number: GALE|A670225504