Enantioselective Radical Cyclization for Construction of 5-Membered Ring Structures by Metalloradical C-H Alkylation

Citation metadata

Date: Apr. 11, 2018
From: Journal of the American Chemical Society(Vol. 140, Issue 14)
Publisher: American Chemical Society
Document Type: Report
Length: 90 words

Document controls

Main content

Abstract :

Guided by the concept of metalloradical catalysis, a different mode of radical cyclization which can employ saturated C?H substrates is demonstrated through the development of a Co(II)-based system for catalytic activation of aliphatic diazo compounds for enantioselective radical alkylation of various C(sp3)?H bonds. It allows for efficient construction of chiral pyrrolidines and other valuable 5-membered cyclic compounds. This alternative strategy of radical cyclization provides a new retrosynthetic paradigm to prepare five-membered cyclic molecules from readily available open-chain aldehydes through the union of C?H and C=O elements for C?C bond formation.

Source Citation

Source Citation   

Gale Document Number: GALE|A540750396