Nanoscale Metal-Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy

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From: Journal of the American Chemical Society(Vol. 140, Issue 17)
Publisher: American Chemical Society
Document Type: Report
Length: 61 words

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Abstract :

The article reports a nanoscale metal-organic framework, Fe-TBP, as a novel nanophotosensitizer to overcome tumor hypoxia and sensitize effective photodynamic therapy (PDT), priming non-inflamed tumors for cancer immunotherapy. Fe-TBP is built from iron-oxo clusters and porphyrin ligands and sensitized PDT under both normoxic and hypoxic conditions. Mechanistic studies reveal that Fe-TBP mediated PDT induced significant tumor infiltration of cytotoxic T cells.

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Gale Document Number: GALE|A541597568