Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models.

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From: Journal of Clinical Investigation(Vol. 131, Issue 11)
Publisher: American Society for Clinical Investigation
Document Type: Report
Length: 11,016 words
Lexile Measure: 1460L

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Abstract :

Hypoxia, a hallmark feature of the tumor microenvironment, causes resistance to conventional chemotherapy, but was recently reported to synergize with poly(ADP-ribose) polymerase inhibitors (PARPis) in homologous recombination-proficient (HR-proficient) cells through suppression of HR. While this synergistic killing occurs under severe hypoxia (

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Gale Document Number: GALE|A664447468