Causal linkage between adult height and kidney function: An integrated population-scale observational analysis and Mendelian randomization study.

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Date: July 29, 2021
From: PLoS ONE(Vol. 16, Issue 7)
Publisher: Public Library of Science
Document Type: Report
Length: 7,037 words
Lexile Measure: 1600L

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Abstract :

As adult height is linked to various health outcomes, further investigation of its causal effects on kidney function later in life is warranted. This study involved a cross-sectional observational analysis and summary-level Mendelian randomization (MR) analysis. First, the observational association between height and estimated GFR determined by creatinine (eGFR.sub.creatinine) or cystatin C (eGFR.sub.cystatinC) was investigated in 467,182 individuals aged 40-69 using UK Biobank. Second, the genetic instrument for adult height, as reported by the GIANT consortium, was implemented, and summary-level MR of eGFR.sub.creatinine and CKD.sub.creatinine in a CKDGen genome-wide association study was performed (N = 567,460), with multivariable MR being adjusted for the effects of genetic predisposition on body mass index. To replicate the findings, additional two-sample MR using the summary statistics of eGFR.sub.cystatinC and CKD.sub.cystatinC in UK Biobank was performed (N = 321,405). In observational analysis, adult height was inversely associated with both eGFR.sub.creatinine (per 1 SD, adjusted beta -1.039, standard error 0.129, P

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Gale Document Number: GALE|A670025511