A 71-kilodalton protein is a major product of the Duchenne muscular dystrophy gene in brain and other nonmuscle tissues

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Publisher: National Academy of Sciences
Document Type: Article
Length: 79 words

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Abstract :

The major gene product of the Duchenne muscular dystrophy (DMD) gene is identified by a 6. 5-kb mRNA transcript detected in many nonmuscle cells including the brain. The DNA region coding for this transcript was cloned and expressed, resulting in the identification of the protein in Western blots of cell extracts. This 71-kilodalton protein differed greatly from dystrophin, although some regions of homology were detected. Its levels in nonmuscle tissues were comparable to the amounts of dystrophin in muscles.

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Gale Document Number: GALE|A13599010