Activated protein C resistance assay when applied in the general population

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Publisher: Elsevier B.V.
Document Type: Article
Length: 95 words

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Abstract :

Screening populations for the presence of factor V Leiden to prevent deaths from blood clots may not be cost effective. The presence of factor V Leiden in blood indicates resistance to the anticoagulant properties of activated protein C, a condition which can lead to easily formed blood clots especially during pregnancy or when taking oral contraceptives. Researchers estimated the cost effectiveness of screening three hypothetical populations. A population with a 2% rate of factor V Leiden would have a false-positive rate of 56% and screening would cost $44,180,000 to prevent one death from blood clots.

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Source Citation   

Gale Document Number: GALE|A19210501