Left ventricular regional wall curvedness and wall stress in patients with ischemic dilated cardiomyopathy

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Publisher: American Physiological Society
Document Type: Author abstract; Report
Length: 302 words

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Abstract :

Geometric remodeling of the left ventricle (LV) after myocardial infarction is associated with changes in myocardial wall stress. The objective of this study was to determine the regional curvatures and wall stress based on three-dimensional (3-D) reconstructions of the LV using MRI. Ten patients with ischemic dilated cardiomyopathy (IDCM) and 10 normal subjects underwent MRI scan. The IDCM patients also underwent delayed gadolinium-enhancement imaging to delineate the extent of myocardial infarct. Regional curvedness, local radii of curvature, and wall thickness were calculated. The percent curvedness change between end diastole and end systole was also calculated. In normal heart, a short-and long-axis two-dimensional analysis showed a 41 [+ or -] 11% and 45 [+ or -] 12% increase of the mean of peak systolic wall stress between basal and apical sections, respectively. However, 3-D analysis showed no significant difference in peak systolic wall stress from basal and apical sections (P = 0.298, ANOVA). LV shape differed between IDCM patients and normal subjects in several ways: LV shape was more spherical (sphericity index = 0.62 [+ or -] 0.08 vs. 0.52 [+ or -] 0.06, P three-dimensional modeling; left ventricle; curvature; cine magnetic resonance imaging; human heart

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Gale Document Number: GALE|A195981647