Treatment with marine collagen peptides modulates glucose and lipid metabolism in Chinese patients with type 2 diabetes mellitus

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Date: Dec. 2010
Publisher: NRC Research Press
Document Type: Report
Length: 5,298 words
Lexile Measure: 1490L

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Abstract :

This study was aimed at examining the therapeutic effects of marine collagen peptides (MCPs) from fish hydrolysate in Chinese patients with type 2 diabetes mellitus (T2DM). A total of 100 diabetic patients and 50 healthy controls were recruited. Diabetic patients were randomized into treatment and control groups. The patients in the treatment group received an additional 13 g of MCPs daily for 3 months. Their blood samples were collected before, and 1.5 and 3 months after, treatment to evaluate glucose and lipid metabolism. The levels of serum high-sensitivity C-reactive protein (hsCRP), nitric oxide (NO), bradykinin, prostacyclin ([PGI.sub.2]), and adipokines were determined. Significantly reduced levels of fasting blood glucose, human glycated hemoglobin A1c (GHbA1c), fasting blood insulin, total triglycerides, total cholesterol, low-density lipoprotein, and free-fatty acids, but increased levels of insulin sensitivity index and HDL were observed in T2DM patients following treatment with MCPs for 1.5 and 3 months. The values of these measures were significantly lower or higher than those of patient controls (p Key words: marine collagen peptide, type 2 diabetes mellitus, insulin sensitivity, adipokine, inflammation. Cette etude se propose d'analyser chez des Chinois aux prises avec le diabete de type 2 (T2DM) les effets theerapeutiques des peptides de collagene marin issus d'un hydrolysat de poisson (MCPs). Au total, on sollicite 100 diabetiques et 50 personnes en bonne sante. On divise aleeatoirement les diabetiques en deux groupes, l'un experimental et l'autre, de controle. Les diabetiques du groupe experimental recjoivent en plus 13 g de MCPs tous les jours, et ce, durant 3 mois. On preleve des eechantillons sanguins avant et 1,5 mois puis 3 mois apresle debut du traitement pour evaluer le meetabolisme du glucose et des lipides. On evalue les concentrations seriques de la proteine C-reactive a haute sensibilite (hsCRP), de l'oxyde nitrique (NO), de la bradykinine, de la prostacycline ([PGI.sub.2]) et des adipokines. Apres 1,5 et 3 mois d'apport de MCPs chez des T2DM du groupe experimental, on observe une diminution significative de la concentration sanguine de glucose et d'insuline a jeun, de GHbA1c, totales des triglycerides, totale de cholesterol, des lipoproteines a faible densite, des acides gras libres et une augmentation de l'index de sensibilite; a l'insuline et de la concentration des HDL. Les valeurs des mesures sont significativement plus faibles ou plus fortes respectivement que celles des diabetiques de controle (p Mots-cles: peptides de collagene marin, diabete de type 2, sensibilite; a l'insuline, adipokine, inflammation. [Traduit par la Redaction]

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Gale Document Number: GALE|A250578734