Treating Clostridium difficile infection

Citation metadata

Date: Apr. 15, 2014
Publisher: CMA Joule Inc.
Document Type: Article
Length: 454 words
Lexile Measure: 2010L

Document controls

Main content

Article Preview :

1 First-line treatment for mild or moderate Clostridium difficile infection is metronidazole; vancomycin is first-line treatment for severe infection

A randomized controlled trial (RCT) showed that metronidazole was as effective as vancomycin taken orally for the treatment of mild Clostridium difficile infection. However, in cases of severe infection, 97% of patients given vancomycin had clinical resolution compared with only 76% of those given metronidazole. (1) The Society for Healthcare Epidemiology of America and the Infectious Diseases Society of America recommend metronidazole as first-line therapy for mild or moderate C. difficile infection and vancomycin for severe infection (Box 1). (2) Although criteria for severe infection differ between guideline and trial, both include a leukocyte count...

Source Citation

Source Citation   

Gale Document Number: GALE|A366082865