A Coagulation-Related Gene-Based Prognostic Model for Invasive Ductal Carcinoma.

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Date: Sept. 21, 2021
Publisher: Frontiers Research Foundation
Document Type: Article
Length: 455 words
Lexile Measure: 1420L

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Author(s): Jing Li, Jiajia Du, Yanhong Wang, Hongyan Jia

<bold>Background:</bold> Invasive ductal carcinoma (IDC) is the most common type of metastatic breast cancer. Due to the lack of valuable molecular biomarkers, the diagnosis and prognosis of IDC remain a challenge. A large number of studies have confirmed that coagulation is positively correlated with angiogenesis-related factors in metastatic breast cancer. Therefore, the purpose of this study was to construct a COAGULATION-related genes signature for IDC using the bioinformatics approaches.

<bold>Methods:</bold> The 50 hallmark gene sets were obtained from the molecular signature database (MsigDB) to conduct Gene Set Variation Analysis (GSVA). Gene Set Enrichment Analysis (GSEA) was applied to analyze the enrichment of HALLMARK_COAGULATION. The...

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Gale Document Number: GALE|A676308058