Crosstalk between ILC2s and Th2 CD4[sup.+] T Cells in Lung Disease.

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Authors: Lan-lan Mi and Wei-wei Guo
Date: May 10, 2022
Publisher: Hindawi Limited
Document Type: Article
Length: 11,786 words
Lexile Measure: 1560L

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Abstract :

Cytokine secretion, such as interleukin-4 (IL-4), IL-5, IL-9, IL-13, and amphiregulin (Areg), by type 2 innate lymphoid cells (ILC2s) is indispensable for homeostasis, remodeling/repairing tissue structure, inflammation, and tumor immunity. Often viewed as the innate cell surrogate of T helper type 2 (Th2) cells, ILC2s not only secrete the same type 2 cytokines, but are also inextricably related to CD4[sup.+]T cells in terms of cell origin and regulatory factors, bridging between innate and adaptive immunity. ILC2s interact with CD4[sup.+]T cells to play a leading role in a variety of diseases through secretory factors. Here, we review the latest progress on ILC2s and CD4[sup.+]T cells in the lung, the close relationship between the two, and their relevance in the lung disease and immunity. This literature review aids future research in pulmonary type 2 immune diseases and guides innovative treatment approaches for these diseases.

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Gale Document Number: GALE|A704638232