Validation of a novel noninvasive cardiac index of left ventricular contractility in patients

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Publisher: American Physiological Society
Document Type: Author abstract
Length: 293 words

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Abstract :

Although there are several excellent indexes of myocardial contractility, they require accurate measurement of pressure via left ventricular (LV) catheterization. Here we validate a novel noninvasive contractility index that is dependent only on lumen and wall volume of the LV chamber in patients with normal and compromised LV ejection fraction (LVEF). By analysis of the myocardial chamber as a thick-walled sphere, LV contractility index can be expressed as maximum rate of change of pressure-normalized stress (d[[sigma].sup.*]/d[t.sub.max], where [[sigma].sup*] = [sigma]/P and [sigma] and P are circumferential stress and pressure, respectively). To validate this parameter, d[[sigma].sup.*]/d[t.sub.max] was determined from contrast cine-ventriculography-assessed LV cavity and myocardial volumes and compared with LVEF, dP/d[t.sub.max], maximum active elastance ([E.sub.a,max]), and single-beat end-systolic elastance [[E.sub.es(SB)]] in 30 patients undergoing clinically indicated LV catheterization. Patients with different tertiles of LVEF exhibit statistically significant differences in d[[sigma].sup.*]/d[t.sub.max]. There was a significant correlation between d[[sigma].sup.*]/d[t.sub.max] and dP/d[t.sub.max] (d[[sigma].sup.*]/ d[t.sub.max] = 0.0075dP/d[t.sub.max] - 4.70, r = 0.88, P cardiac mechanics; ventricular elastance; ventriculography; wall stress doi:10.1152/ajpheart.00540.2006

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Gale Document Number: GALE|A165911490