Abstract :
Byline: Albert Altes, Joan C. Souto, Jose Mateo, Montse Borrell, Jordi Fontcuberta Keywords: Activated protein C resistance,; factor V Leiden,; thrombosis,; oral contraceptives,; pregnancy Abstract: We estimated the predictive values of activated protein C resistance in the diagnosis of women who are carriers of factor V Leiden. When the prevalence of factor V Leiden is 2%, the positive predictive value is 44% and the cost of preventing one thromboembolic death is $44,180,000. Thus the activated protein C resistance assay is not cost-effective in ruling out factor V Leiden in this population. (Am J Obstet Gynecol 1997;176:358-9.) Author Affiliation: Barcelona, Spain Article History: Received 7 February 1996; Revised 30 July 1996; Accepted 10 October 1996 Article Note: (footnote) [star] From the Thrombosis and Haemostasis Unit, the Department of Hematology, Hospital de la Santa Creu I Sant Pau de Barcelona,a and Hospital Esperit Sant, Santa Coloma de Gramanet.b , [star][star] Supported in part by a grant from Fondo de Investigaciones Sanitarias FIS 94/39., a Reprints not available from the authors., aa 6/1/78528