Guanylyl cyclase-D in the olfactory C[O.sub.2] neurons is activated by bicarbonate

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Date: Feb. 10, 2009
Publisher: National Academy of Sciences
Document Type: Author abstract
Length: 145 words

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Abstract :

Atmospheric C[O.sub.2] is an important environmental cue that regulates several types of animal behavior. In mice, C[O.sub.2] responses of the olfactory sensory neurons (OSNs) require the activity of carbonic anhydrase to catalyze the conversion of C[O.sub.2] to bicarbonate and the opening of cGMp-sensitive ion channels. However, it remains unknown how the enhancement of bicarbonate levels results in cGMP production. Here, we show that bicarbonate activates cGMP-producing ability of guanylyl cyclase-D (GC-D), a membrane GC exclusively expressed in the C[O.sub.2]-responsive OSNs, by directly acting on the intracellular cyclase domain of GC-D. Also, the molecular mechanism for GC-D activation is distinct from the commonly believed model of "release from repression" for other membrane GCs. Our results contribute to our understanding of the molecular mechanisms of C[O.sub.2] sensing and suggest diverse mechanisms of molecular activation among membrane GCs. carbonic anhydrase | CNG channels | necklace glomeruli | transduction

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Gale Document Number: GALE|A194620191