Search for Bactericides Among Derivatives of Deoxyvasicinone, Mackinazolinone, and Thienopyrimidinones

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From: Pharmaceutical Chemistry Journal(Vol. 51, Issue 6)
Publisher: Springer
Document Type: Article
Length: 5,993 words
Lexile Measure: 1620L

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Abstract :

Series of arylidene- and arylhydroxymethyl derivatives of 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-one and 2,3,4,10-tetrahydro-1H-pyrido[2,1-b]quinazolin-10-one were synthesized. Schiff bases were synthesized from amine derivatives. Hydroxymethylidene derivatives and arylaminomethylidene-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-9-ones and -2,3,4,10-tetrahydro-1H-pyrido[2,1-b]quinazolin-10-ones were obtained. The antimicrobial activity of the synthesized compounds against S. aureus, E. coli, Bacillus cereus, Candida albicans, and Pseudomonas aeruginosa was studied. It was concluded that the search for bactericides in these series was promising.

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Gale Document Number: GALE|A510372714