Elevated fecal calprotectin is linked to psychosocial complexity in pediatric functional abdominal pain disorders.

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From: BMC Research Notes(Vol. 14, Issue 1)
Publisher: BioMed Central Ltd.
Document Type: Report
Length: 3,069 words
Lexile Measure: 1460L

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Abstract :

Objective Children with functional abdominal pain disorders (FAPD) and clinical elevations in three risk areas (anxiety, functional disability, and pain) have been found to be at increased risk for persistent disability. We evaluated if the presence of these three risk factors corresponded with greater gastrointestinal inflammation (measured via fecal calprotectin; FC) compared to those with no risk factors. FC concentration differences between children with three risk factors and those with one and two risk factors were explored. Results Fifty-six children with FAPD (M.sub.age = 12.23) completed measures of anxiety (Screen for Child Anxiety Related Disorders), disability (Functional Disability Inventory), and pain intensity (Numeric Rating Scale). Participants were stratified into risk groups (range: 0-3). Fisher's exact tests were conducted to determine if children with three versus fewer risk factors were more likely to have elevated FC ([greater than or equai to] 50 [micro]g/g) versus normal levels. Children with three risk factors (M.sub.FC = 86.04) were more likely to have elevated FC compared to children with zero (M.sub.FC = 25.78), one (M.sub.FC = 38.59), and two risk factors (M.sub.FC = 45.06; p's Keywords: Fecal calprotectin, Functional disability, Anxiety

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Gale Document Number: GALE|A678017978