Potential Involvement of LOX-1 in Functional Consequences of Endothelial Senescence

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Date: June 15, 2011
From: PLoS ONE(Vol. 6, Issue 6)
Publisher: Public Library of Science
Document Type: Article
Length: 4,211 words
Lexile Measure: 1400L

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Abstract :

Numerous studies have described the process of senescence associated with accumulation of oxidative damage, mutations and decline in proliferative potential. Although the changes observed in senescent cells are likely to result in significant phenotypic alterations, the studies on consequences of endothelial senescence, especially in relation to aging-associated diseases, are scarce. We have analyzed effects of senescence on the functions of endothelial cells relevant to the development of atherosclerosis including angiogenesis, adhesion, apoptosis and inflammation. In the course of progressing through the passages, human umbilical vein endothelial cells (HUVECs) displayed significant increase in size (+36% passage 12 vs. passage 4, p

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Gale Document Number: GALE|A476888178