LOX-1, oxidant stress, mtDNA damage, autophagy, and immune response in atherosclerosis

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Publisher: NRC Research Press
Document Type: Report
Length: 3,594 words
Lexile Measure: 1440L

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Abstract :

As a major receptor for oxidized low density lipoprotein (ox-LDL), lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is upregulated in many pathophysiological events, including endothelial cell dysfunction and smooth muscle cell growth, as well as monocyte migration and transformation into foam cells, which are present in atherosclerosis and myocardial ischemia. Excessive production of reactive oxygen species (ROS) increases LOX-1 expression, induces mitochondrial DNA damage, and activates autophagy. Damaged mitochondrial DNA that escapes from autophagy induces an inflammatory response. This paper reviews the potential link between LOX-1, mitochondrial DNA damage, autophagy, and immune response in atherosclerosis. Key words: LOX-1, mitochondrial DNA, autophagy, immunity, atherosclerosis, reactive oxygen species, oxidized LDL. En sa qualite de recepteur principal des lipoproteines de faible densite oxydees (ox-LDL), LOX-1 (Lectin-like oxidized low-density lipoprotein receptor-1) est regule a la hausse lors de plusieurs evenements pathophysiologiques dont la dysfonction des cellules endotheliales, la croissance des cellules de muscle lisse, la migration des monocytes et leur transformation en cellules spumeuses, qui sont presentes dans l'atherosclerose et l'ischemie myocardique. Une production excessive d'especes reactives d'oxygene (ERO) accroit l'expression de LOX-1, induit un dommage a l'ADN mitochondrial et active l'autophagie. L'ADN mitochondrial endommage qui evite l'autophagie induit une reponse inflammatoire. Cet article passe en revue le lien potentiel entre LOX-1, le dommage a l'ADN mitochondrial, l'autophagie et la reponse immune dans l'atherosclerose. [Traduit par la Redaction] Mots-cles : LOX-1, ADN mitochondrial, autophagie, immunite, atherosclerose, espece reactive d'oxygene, LDL oxydees.

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Gale Document Number: GALE|A380748080