Neurocognitive endophenotypes in pediatric OCD probands, their unaffected parents and siblings.

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Date: Aug. 30, 2021
Publisher: Elsevier B.V.
Document Type: Report; Brief article
Length: 403 words

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Keywords Endophenotype; Obsessive compulsive disorder; Cognitive functioning; Neuropsychology; Family studies Highlights * A large cohort of pediatric OCD probands, their unaffected siblings and parents completed a neuropsychological battery. * Deficient performance found among OCD probands and unaffected relatives on initial concept formation and proactive control. * These subdomains of cognitive flexibility and inhibitory control may be candidate endophenotypes of OCD. * These results echo the need for a high-resolution examination of secondary neurocognitive outcome measures. Abstract Background Limited extant research on neurocognitive endophenotypes in obsessive-compulsive disorder (OCD) show inconsistent results. Limitations of this body of literature include small sample sizes, strict exclusion criteria, lack of objective standard normalized test scores, and significant lack of studies utilizing pediatric probands. This study aimed to address these limitations. Methods A large carefully screened cohort of pediatric OCD (n = 102), their unaffected siblings (n = 78), and parents (n = 164), completed a neuropsychological battery. To compare participants at different ages and developmental stages, standard scores were computed using test norms. Cluster-robust regression with sample size-adjusted sandwich estimates of variance, and interclass correlations were computed. False Discovery Rate procedures were employed to correct for multiplicity. Results Probands, siblings and parents demonstrated deficient task performance (Z Conclusions OCD probands, their unaffected siblings and parents exhibited deficiencies in specific subdomains of cognitive flexibility and inhibitory control, namely, initial concept formation and proactive control, which may be valid candidate neurocognitive endophenotypes of OCD. No other meaningful familial effect has been found on other functions, including other executive function indices such as perseverations and interference control. These results highlight the need to carefully examine individual outcomes from executive function tests instead of the tendency to focus largely on major outcome measures. Author Affiliation: (a) Department of Psychology, Texas State University, San Marcos, TX, USA (b) Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA * Corresponding author at: Department of Psychology, Texas State University, 601 University Drive, San Marcos, TX 78666, USA. Article History: Received 1 November 2020; Revised 28 January 2021; Accepted 10 February 2021 Byline: Amitai Abramovitch [abramovitch@txstate.edu] (a,b,*), Alessandro S. De Nadai (a), Daniel A. Geller (b)

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Gale Document Number: GALE|A665658501