Borchardt, Ronald T; Kerns, Edward H; Lipinski, Christopher A; Thacker, DhirenR; Wang, Binghe (eds): Pharmaceutical Profiling in Drug Discovery for Lead Selection

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Author: Mark Crawford
Date: Feb. 2005
From: Journal of Biomolecular Screening(Vol. 10, Issue 1)
Publisher: Sage Publications, Inc.
Document Type: Article
Length: 1,010 words

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Borchardt, Ronald T; Kerns, Edward H; Lipinski, Christopher A; Thacker, DhirenR; Wang, Binghe (eds): Pharmaceutical Profiling in Drug Discovery for Lead Selection. Arlington (VA): American Association of Pharmaceutical Scientists, 2004. 482 p. (ISBN: 0-9711767-9-5)

This book comes out of the May 2003workshop of the same title sponsored by the American Association of Pharmaceutical Scientists, the American Chemical Society, Medicinal Chemistry Division, and the Society for Biomolecular Screening. The individual chapters were written by distinguished workshop speakers from the pharmaceutical industry and academia. This book provides broad coverage of technologies and strategies for the integration of desirable pharmaceutical properties into the drug discovery process. The content can be thought of in 3 dimensions: first from the axis of experimental approach--from computational techniques through in vitro assay technologies and on to in vivo considerations; second from the axis of specific property or physiological consideration--solubility, lipophilicity, stability, absorption, distribution, metabolism, and toxicity; and third from the axis of perspective--specific methods to general strategies and guidelines.

The authors and editors have put together a book that covers these broad fields remarkably well. This book will be of interest and of practical value to everyone involved in drug discovery. It is an excellent source of information on fundamental principles, specific guidelines, and general strategies from a variety of perspectives. Unavoidably, the book suffers from the downside of any volume made from the collective contributions of many authors with diverse perspectives. To get all of the information on 1 topic, one should read the whole book. For example,...

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Gale Document Number: GALE|A140794701