Disseminated Nocardiosis in renal transplant recipient under therapy for pulmonary tuberculosis: a case report

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From: BMC Research Notes(Vol. 10, Issue 1)
Publisher: BioMed Central Ltd.
Document Type: Author abstract; Clinical report
Length: 2,819 words
Lexile Measure: 1480L

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Abstract :

Background Nocardiosis is an opportunistic infection in a patient with underlying immune suppression and organ transplant. Clinical syndromes are varied and ranges from pulmonary, disseminated, cutaneous along with central nervous system involvement. Case presentation Herein, we report a rare case of disseminated pulmonary nocardiosis with cerebral manifestation in a 66 year-old-Nepali farmer; with a history of renal transplantation and undergoing therapy for pulmonary tuberculosis. Radiographic imaging revealed multiple opacities of varying sizes in bilateral lung field mediastinal, retroperitoneal lymphadenopathy, and ill-defined lesion with surrounding edema seen in left occipitoparietal region of brain. Bacteriological assessments of bronchoalveolar lavage and purulent fluid extracted intra-operatively from the lesion confirmed the case as Nocardiosis. Conclusion Disseminated Pulmonary nocardiosis with central nervous system involvement carries a poor prognosis. However, early diagnosis of the case, the administration of appropriate antibiotic, stereotactic aspiration alone or craniotomy has a successful outcomes even in a post renal transplant patient treated with anti tuberculosis treatment. Keywords: Disseminated Nocardiosis, Pulmonary tuberculosis, Renal transplant, Cerebral abscesses, Immune suppression

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Gale Document Number: GALE|A480552474