The role of innate immunity in HBV infection

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Date: Jan. 2013
From: Seminars in Immunopathology(Vol. 35, Issue 1)
Publisher: Springer
Document Type: Report
Length: 239 words

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Abstract :

Byline: Qiuju Han (1), Cai Zhang (1), Jian Zhang (1), Zhigang Tian (1,2) Keywords: HBV; Innate immunity; NK; NKT; PRR Abstract: Hepatitis B virus (HBV) infection is one of the main causes of chronic liver diseases. Whether HBV infection is cleared or persists is determined by both viral factors and host immune responses. It becomes clear that innate immunity is of importance in protecting the host from HBV infection and persistence. However, HBV develops strategies to suppress the antiviral immune responses. A combined therapeutic strategy with both viral suppression and enhancement of antiviral immune responses is needed for effective long-term clearance and cure for chronic HBV infection. We and others confirmed that bifunctional siRNAs with both gene silencing and innate immune activation properties are beneficial for inhibition of HBV and represent a potential approach for treatment of viral infection. Understanding the nature of liver innate immunity and their roles in chronic HBV progression and HBV clearance may aid in the design of novel therapeutic strategies for chronic HBV infection. Author Affiliation: (1) Institute of Immunopharmacology & Immunotherapy, School of Pharmaceutical Sciences, Shandong University, 44 Wenhua West Road, Jinan, 250012, China (2) Institute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, China Article History: Registration Date: 06/07/2012 Received Date: 31/12/2011 Accepted Date: 05/07/2012 Online Date: 20/07/2012 Article note: This article is published as part of the Special Issue on Immunopathology of viral hepatitis [34:4]

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Gale Document Number: GALE|A321734413