This paper investigates the spatiotemporal variability in hydrometeorological time-series to evaluate the current and future scenarios of water resources availability from upper Indus basin (UIB). Mann-Kendall and Sen's slope estimator tests were used to analyze the variability in the temperature, precipitation, and streamflow time-series data at 27 meteorological stations and 34 hydrological stations for the period of 1963 to 2014. The time-series data of entire study period were divided into two equal subseries of 26 years each (1963-1988 and 1989-2014) to assess the overlapping aspect of climate change acceleration over UIB. The results showed a warming pattern at low altitude stations, while a cooling tendency was detected at high-altitude stations. An increase in streamflow was detected during winter and spring seasons at all hydrological stations, whereas the streamflow in summer and autumn seasons exhibited decreasing trends. The annual precipitation showed a significant decreasing trend at ten stations, while a significant increasing trend was observed at Kohat station during second subseries of the study period. The most significant winter drying trends were observed at Gupis, Chitral, Garidopatta, and Naran stations of magnitude of 47%, 13%, 25%, and 18%, respectively, during the second subseries. The annual runoff exhibited significant deceasing trends over Jhelum subbasin at Azad Pattan, Chinari, Domel Kohala, Muzaffarabad, and Palote, while within Indus basin at Chahan, Gurriala, Khairabad, Karora, and Kalam in the second time-series. It is believed that the results of this study will be helpful for the decision-makers to develop strategies for planning and development of future water resources projects.