GAPGOM--an R package for gene annotation prediction using GO Metrics.

Citation metadata

Date: Apr. 30, 2021
From: BMC Research Notes(Vol. 14, Issue 1)
Publisher: BioMed Central Ltd.
Document Type: Report
Length: 2,647 words
Lexile Measure: 1450L

Document controls

Main content

Abstract :

Objective Properties of gene products can be described or annotated with Gene Ontology (GO) terms. But for many genes we have limited information about their products, for example with respect to function. This is particularly true for long non-coding RNAs (lncRNAs), where the function in most cases is unknown. However, it has been shown that annotation as described by GO terms to some extent can be predicted by enrichment analysis on properties of co-expressed genes. Results GAPGOM integrates two relevant algorithms, lncRNA2GOA and TopoICSim, into a user-friendly R package. Here lncRNA2GOA does annotation prediction by co-expression, whereas TopoICSim estimates similarity between GO graphs, which can be used for benchmarking of prediction performance, but also for comparison of GO graphs in general. The package provides an improved implementation of the original tools, with substantial improvements in performance and documentation, unified interfaces, and additional features. Keywords: Gene ontology, Annotation, Prediction, Long non-coding RNAs

Source Citation

Source Citation   

Gale Document Number: GALE|A661427835