Relationship between a low ratio of serum estradiol to follicle number and fertility treatment outcomes: A retrospective cohort study of 516 cases

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From: Medicine(Vol. 97, Issue 34)
Publisher: Lippincott Williams & Wilkins, WK Health
Document Type: Author abstract; Report
Length: 262 words

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Byline: Qiaoyao Huang, Reproductive Medicine Center, Affiliated Hospital of Guangdong Medical University; Yanru Niu, Laboratory of Minimally Invasive Orthopedics, Guangdong Medical University, Zhanjiang, Guangdong, China.; Lihua Xu, Reproductive Medicine Center, Affiliated Hospital of Guangdong Medical University; Bi Chen, Reproductive Medicine Center, Affiliated Hospital of Guangdong Medical University; Yunshan Zhang, Reproductive Medicine Center, Affiliated Hospital of Guangdong Medical University; Li Jun Song, Reproductive Medicine Center, Affiliated Hospital of Guangdong Medical University; Xia Jing, Reproductive Medicine Center, Affiliated Hospital of Guangdong Medical University; Bing Wei, Reproductive Medicine Center, Affiliated Hospital of Guangdong Medical University; Tianzhong Ma, Reproductive Medicine Center, Affiliated Hospital of Guangdong Medical University Abstract The aim of this retrospective study was to examine how a low estradiol/follicle (E2/fol) may be related to in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI)-embryo transfer outcomes in polycystic ovary syndrome (PCOS) and non-PCOS patients, respectively. Between 2013 and 2017, 516 IVF/ICSI cycles (146 cycles in PCOS patients and 370 cycles in non-PCOS patients) with a long gonadotrophin releasing hormone receptor agonist protocol-including 338 involved fresh transfer cycles (89 cycles in PCOS patients and 249 cycles in non-PCOS patients)-were conducted. Outcomes were compared between 5 groups of PCOS patients defined by E2/fol (pg/mL) as follows: A, 350. Non-PCOS patients' outcomes are grouped as well. Whether in PCOS or non-PCOS patients, those in the lowest E2/fol group ( .05). Whether in PCOS or non-PCOS patients, greater BMI, greater AFC, and younger age may favor the phenomenon of low E2/fol. In turn, low E2/fol may reduce the oocyte retrieval rate and increase the risk of 1PN and 3PN formation and abortion.

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Gale Document Number: GALE|A551391262