Adipokines and Chronic Rheumatic Diseases: from Inflammation to Bone Involvement.

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Publisher: Springer
Document Type: Report; Brief article
Length: 195 words

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Abstract :

Keywords: Adipokines; Rheumatoid arthritis; Spondyloarthritis; Inflammation Abstract Besides its well-known role as energy storage tissue, adipose tissue is a biologically active tissue that can also be considered as an endocrine organ, as it is able to secrete adipokines. These bioactive factors, similar in structure to cytokines, are involved in several physiological and pathological conditions, such as glucose homeostasis, angiogenesis, blood pressure regulation, control of food intake, and also inflammation and bone homeostasis via endocrine, paracrine, and autocrine mechanisms. Given their pleiotropic functions, the role of adipokines has been evaluated in chronic rheumatic osteoarticular inflammatory diseases, particularly focusing on their effects on inflammatory and immune response and on bone alterations. Indeed, these diseases are characterized by different bone complications, such as local and systemic bone loss and new bone formation. The aim of this review is to summarize the role of adipokines in rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, osteoarthritis, and osteoporosis, especially considering their role in the pathogenesis of bone complications typical of these conditions. Author Affiliation: (1) Department of Medical and Surgical Sciences, Rheumatology Clinic, University of Foggia, Foggia, Italy (a) Article History: Registration Date: 02/26/2021 Accepted Date: 02/26/2021 Online Date: 03/09/2021 Byline:

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Gale Document Number: GALE|A675324565