Relation of alleles of the collagen type I alpha 1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women

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From: The New England Journal of Medicine(Vol. 338, Issue 15)
Publisher: Massachusetts Medical Society
Document Type: Article
Length: 86 words

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Abstract :

Variations in a gene for a type of bone matrix collagen may cause a decrease in bone mineral density and increase the risk of osteoporosis-related fractures in older women. Researchers analyzed the COLIA1 gene in 1,778 postmenopausal women, and found that particular variations were associated with 2% to 6% reductions in bone mineral density and higher rates of bone fractures. Among the oldest women tested, bone density was reduced as much as 20% in those with the least-favorable variation, compared with those with the most-favorable variation.

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Gale Document Number: GALE|A20507780