Soluble ST2 plasma concentrations predict mortality in severe sepsis

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From: Intensive Care Medicine(Vol. 36, Issue 4)
Publisher: Springer
Document Type: Author abstract; Report
Length: 331 words

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Byline: Jacobien J. Hoogerwerf (1,2), Michael W. T. Tanck (3), Marieke A. D. Zoelen (1,2), Xavier Wittebole (4), Pierre-Francois Laterre (4), Tom Poll (1,2) Keywords: ST2; Sepsis; Innate immune response; Cytokines Abstract: Purpose Patients with sepsis--after surviving the initial hyperinflammatory phase--display features consistent with immunosuppression, including hyporesponsiveness of immunocompetent cells to bacterial agents. Immunosuppression is thought to be facilitated by negative regulators of toll-like receptors, including membrane-bound ST2. We investigated the release of soluble ST2 (sST2), a decoy receptor that inhibits membrane-bound ST2 signaling, during sepsis. Methods The study population comprised 95 patients with severe sepsis admitted to one of two intensive care units (ICUs) at the day the diagnosis of severe sepsis was made. Blood was obtained daily from admission (day 0) until day 7 and finally at day 14. Twenty-four healthy subjects served as controls. sST2 and cytokines were measured in serum. Results Mortality among patients was 34% in the ICU and 45% in the hospital. On admission, sepsis patients had higher sST2 levels [10,989 (7,871--15,342) pg/ml, geometric mean (95% confidence interval, CI)] than controls [55 (20--145) pg/ml, P Conclusions Sepsis results in sustained elevation of serum sST2 levels, which correlates with disease severity and mortality. Author Affiliation: (1) Center for Infection and Immunity Amsterdam (CINIMA), University of Amsterdam, Amsterdam, The Netherlands (2) Center of Experimental and Molecular Medicine, University of Amsterdam, Meibergdreef 9, Room G2-132, 1105 AZ, Amsterdam, The Netherlands (3) Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (4) Department of Intensive Care and Emergency Medicine, St. Luc University Hospital, UCL, Brussels, Belgium Article History: Registration Date: 26/01/2010 Received Date: 28/08/2008 Accepted Date: 03/11/2009 Online Date: 12/02/2010

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Gale Document Number: GALE|A221025244