Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells

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Publisher: National Academy of Sciences
Document Type: Author abstract; Report
Length: 118 words

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Abstract :

T-cell receptor (TCR) signal strength determines selection and lineage fate at the [CD4.sup.+][CD8.sup.+] double-positive stage of intrathymic T-cell development. Members of the miR-181 family constitute the most abundantly expressed microRNA at this stage of T-cell development. Here we show that deletion of miR-181a/b-1 reduced the responsiveness of double-positive thymocytes to TCR signals and virtually abrogated early invariant natural killer T (iNKT) cell development, resulting in a dramatic reduction in iNKT cell numbers in thymus as well as in the periphery. Increased concentrations of agonist ligand rescued iNKT cell development in miR-181a/[b-1.sup.-/-] mice. Our results define a critical role of miR-181a/b-1 in early iNKT cell development and show that miR-181a/b-1 sets a TCR signaling threshold for agonist selection.

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Gale Document Number: GALE|A332021632