This study investigated the ability to sustain quadriceps central motor drive while subjected to localized heat and metaboreceptive feedback from the contralateral leg. Eight active males each completed two counter-balanced trials, in which muscle temperature ([T.sub.m]) of a single-leg (TEMP-LEG) was altered to 29.4[degrees]C (COOL) or 37.6[degrees]C (WARM), while the contralateral leg (CL-LEG) remained thermoneutral: 35.3[degrees]C and 35.2[degrees]C [T.sub.m] in COOL and WARM, respectively. To activate metaboreceptive feedback, participants first performed one 120-s isometric maximal voluntary contraction (MVC) of the knee extensors in the TEMP-LEG, immediately followed by postexercise muscle ischemia (PEMI) via femoral blood flow occlusion. To assess central motor drive of a remote muscle group immediately following PEMI, another 120-s MVC was subsequently performed in the CL-LEG. Voluntary muscle activation (VA) was assessed using the twitch interpolation method. Perceived mental effort and limb discomfort were also recorded. In a cooled muscle, a significant increase in mean force output and mean VA (force, P 0.68; and limb discomfort. P = 0.73). The present findings suggest that elevated local skin temperature and Tm can increase limb discomfort and decrease central motor drive, but this does not limit systemic motor activation of a thermoneutral muscle group. doi: 10.1152/ajpregu.00055.2017.