Antibiotic susceptibility and drug prescription pattern in uropathogenic Escherichia coli in district Muzaffarabad, Azad Jammu and Kashmir, Pakistan

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From: Journal of Pakistan Medical Association(Vol. 70, Issue 11)
Publisher: Knowledge Bylanes
Document Type: Report
Length: 1,731 words
Lexile Measure: 1590L

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Byline: Ghazanfar Ali, Sardar Riaz-Ul-Hassan, Sadia, Muhammad Ali Shah, Muhammad Qudir Javid, Abdul Rehman Khan and Lubna Shakir

Keywords: Antibiotic susceptibility patterns, Escherichia coli, Urinary tract infection patients, Empirical treatment.

Introduction

Urinary tract infections(UTI) are one of the most common bacterial infections diagnosed in both outpatients as well as in hospitalised patients. Each year 150 million cases of UTI are reported worldwide, resulting in a significant increase in healthcare associated expenditure.1 Although UTI affects both sexes, it is more common in women than men. It has been reported that every second woman contract UTI at least once in her life.2 More than 80% UTI infections are caused by Escherichia coli(E. coli),commensal gram-negative bacteria, inhabiting the colon of warm blooded animals.3

Empirical treatment based on global data of antimicrobial susceptibility is the most preferred method to treat UTI. This global antimicrobial susceptibility data is not constant and varies from time to time and from place to place.4 Empirical treatment of UTI without local antimicrobial susceptibility data may lead to misuse of antibiotics and will end up in increasing antibiotic resistance. Updated knowledge of local hospital-based antibiotic susceptibility of uropathogens is important for ensuring appropriate therapy and minimising the threat of antibiotic resistance.

The present study was carried out to investigate the prevalence and antibiotic susceptibility patterns of E. coli isolated from patients affected with UTI against antibiotics frequently used in empirical treatment of UTI in two main hospitals, AIMS and CMH of district Muzaffarabad, Azad Jammu and Kashmir(AJK).

Table-1: Gender wise prevalence of UTI at AIMS and CMH.

Hospital###Age Group###Male [n(%)]###Female[n(%)]

AIMS (n=50)###20 months 68 year###17 (34)###33 (66)

CMH (n=50)###1-60years###16 (32)###34 (68)

Table-2: Antibiotic response pattern of E. coli isolates from AIMS hospital.

Drugs###Sample Size###Sensitive###Resistant [n(%)]

Imipenem###50###50###0 (0)

Ciprofloxacin###50###23###27 (54)

Cefixime###50###3###47 (94)

Co-Amoxiclave###50###18###32 (64)

Pipemedic Acid###50###12###38 (76)

Nitrofurantoin###50###45###5 (10)

Co-Trimoxazole###50###20###30 (60)

Table-3: Antibiotic response pattern of E. coli isolates from CMH hospital.

Drugs###Sample Size###Sensitive###Resistant [n(%)]

Imipenem###50###50###0 (0)

Ciprofloxacin###50###32###18 (36)

Cefixime###50###16###34 (68)

Co-Amoxiclave###50###13###37 (74)

Pipemedic Acid###50###20###30 (60)

Nitrofurantoin###50###46###4 (8)

Co-Trimoxazole###50###3###47 (94)

Methods and Results

The study was carried out in the microbiology laboratory of Abbas Institute of Medical Sciences(AIMS) and Combined Military Hospital(CMH), district Muzaffarabad, AJK, Pakistan.

Urine samples were collected from the OPDs(outpatients departments) and indoor patients of two major hospitals from district Muzaffarabad, AJK, Pakistan. The duration of the study was eight months from November 2016 to June 2017.

Urine samples of 100 patients, comprising 50 males and 50 females, who attended the outpatient departments(OPDs) as well as indoor patients of the two hospitals and had clinical evidence of urinary tract infection, determined by physicians, were included in this study. The age...

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Gale Document Number: GALE|A641916075