The nationwide lockdown was imposed over India from 25 March to 31 May 2020 with varied relaxations from phase I to phase IV to contain the spread of COVID-19. Thus, emissions from industrial and transport sectors were halted during lockdown (LD), which has resulted in a significant reduction of anthropogenic pollutants. The first two lockdown phases were strictly implemented (phase I and phase II) and hence were considered to be total lockdown (TLD) in this study. Satellite-based tropospheric columnar nitrogen dioxide (TCN) from the years 2015 to 2020, tropospheric columnar carbon monoxide (TCC) during 2019/20, and aerosol optical depth (AOD.sub.550) from the years 2014 to 2020 during phase I and phase II LD and pre-LD periods were investigated with observations from Aura OMI, Sentinel-5P TROPOMI, and Aqua and Terra MODIS. To quantify lockdown-induced changes in TCN, TCC, and AOD.sub.550, detailed statistical analysis was performed on de-trended data using the Student paired statistical t test. Results indicate that mean TCN levels over India showed a dip of 18 % compared to the previous year and also against the 5-year mean TCN levels during the phase I lockdown, which was found to be statistically significant (p value 0.05) against the respective period. Furthermore, drastic changes in TCN levels were observed over hotspots, namely eastern region and urban cities. For example, there was a sharp decrease of 62 % and 54 % in TCN levels compared to 2019 and against 5-year mean TCN levels over New Delhi with a p value of 0.0002 (which is statistically significant) during total LD. The TCC levels were high in the northeast (NE) region during the phase I LD period, which is mainly attributed to the active fire counts in this region. However, lower TCC levels are observed in the same region due to the diminished fire counts during phase II. Further, AOD.sub.550 is reduced over the country by â¼ 16 % (Aqua and Terra) from the 6-year (2014-2019) mean AOD.sub.550 levels, with a significant reduction (Aqua MODIS 28 %) observed over the Indo-Gangetic Plain (IGP) region with a p value of âª 0.05. However, an increase in AOD.sub.550 levels (25 % for Terra MODIS, 15 % for Aqua MODIS) was also observed over central India during LD compared to the preceding year and found significant with a p value of 0.03. This study also reports the rate of change of TCN levels and AOD.sub.550 along with statistical metrics during the LD period.