Enantioselective Ni-Al Bimetallic Catalyzed exo-Selective C-H Cyclization of Imidazoles with Alkenes

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Date: Apr. 25, 2018
From: Journal of the American Chemical Society(Vol. 140, Issue 16)
Publisher: American Chemical Society
Document Type: Report
Length: 47 words

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Abstract :

A Ni-Al bimetallic catalyzed enantioselective C-H exo-selective cyclization of imidazoles with alkenes is developed. A series of bi- or polycyclic imidazoles with beta-stereocenter are obtained in up to 98% yield and 99% ee. The bifunctional SPO ligand-promoted bimetallic catalysis proved to be critical to this challenging stereocontrol.

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Source Citation   

Gale Document Number: GALE|A541772015