Suzuki-Miyaura Coupling of Simple Ketones via Activation of Unstrained Carbon-Carbon Bonds

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Date: Apr. 25, 2018
From: Journal of the American Chemical Society(Vol. 140, Issue 16)
Publisher: American Chemical Society
Document Type: Report
Length: 59 words

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Abstract :

The article describes that simple ketones can be efficiently employed as electrophiles in Suzuki-Miyaura coupling reactions via catalytic activation of unstrained C-C bonds. A range of common ketones, such as cyclopentanones, acetophenones, acetone and 1-indanones, could be directly coupled with various arylboronates in high site-selectivity. Preliminary mechanistic study suggests that the ketone alpha-C-C bond is cleaved via oxidative addition.

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Gale Document Number: GALE|A541767169