Asymmetric Total Synthesis of Cyclocitrinol

Citation metadata

From: Journal of the American Chemical Society(Vol. 140, Issue 16)
Publisher: American Chemical Society
Document Type: Report
Length: 56 words

Document controls

Main content

Abstract :

The first and asymmetric total synthesis of cyclocitrinol, an unusual C25 steroid, is accomplished in a linear sequence of 18 steps from commercially available compound 11. The synthetically challenging bicyclo[4.4.1] A/B ring system with a strained bridgehead (anti-Bredt) double bond of cyclocitrinol is constructed efficiently and diastereoselectively via a type II intramolecular [5 + 2] cycloaddition.

Source Citation

Source Citation   

Gale Document Number: GALE|A541772016