Iron-Catalyzed Difluoromethylation of Arylzincs with Difluoromethyl 2-Pyridyl Sulfone

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Date: Jan. 24, 2018
From: Journal of the American Chemical Society(Vol. 140, Issue 3)
Publisher: American Chemical Society
Document Type: Report
Length: 60 words

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Abstract :

The article reports the first iron-catalyzed difluoromethylation of arylzincs with difluoromethyl 2-pyridyl sulfone via selective CuS bond cleavage. This method employs the readily available, bench-stable fluoroalkyl sulfone reagent and inexpensive iron catalyst, allowing facile access to structurally diverse difluoromethylated arenes at low temperatures. The experiment employing a radical clock indicates the involvement of radical species in this iron-catalyzed difluoromethylation process.

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Gale Document Number: GALE|A533972355